WAY-161503

WAY-161503 is a full agonist of 5-HT_2C receptors (K_i = 3.3 nM for displacement of DOI (Item No. 13885)).¹ Relative to 5-HT_2C receptor binding, WAY-161503 is ~6-fold less potent at 5-HT_2A receptors (K_i = 18 nM) and 20-fold less potent at 5-HT_2B receptors (K_i = 60 nM).¹ In functional studies, WAY-161503 can stimulate calcium mobilization coupled to 5-HT_{2C, 2B,} and _2A receptors with EC₅₀ values of 0.8, 1.8, and 7 nM, respectively.¹ WAY-161503 has been reported to produce dose-dependent decreases in food intake in 24-hour fasted normal Sprague-Dawley rats, diet-induced obese mice, and obese Zucker rats with ED₅₀ values of 1.9, 6.8, and 0.73 mg/kg, respectively.¹ This compound has been used to examine the role of 5-HT_2C receptors in rodent models of depression, locomotion, reinforcement, or motivated behaviors.^2,3

WARNING This product is not for human or veterinary use.

1. Rosenzweig-Lipson, S., Zhang, J., Mazandarani, H., et al. Antiobesity-like effects of the 5-HT_2C receptor agonist WAY-161503. Brain Res. 1073-1074, 240-251 (2006).

2. Cryan, J.F., and Lucki, I. Antidepressant-like behavioral effects mediated by 5-Hydroxytryptamine(²C) receptors. J. Pharmacol. Exp. Ther. 295(3), 1120-1126 (2000).

3. Hayes, D.J., Mosher, T.M., and Greenshaw, A.J. Differential effects of 5-HT_2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats. Behav. Brain Res. 197(2), 323-330 (2009).