Thidiazuron

Thidiazuron is a plant growth regulator.¹ It increases soybean callus and radish cotyledon growth when used at concentrations of 5 nM and 50 µM, respectively.¹ Thidiazuron (400 nM for seven weeks) induces the dedifferentiation of, and increases seedling number from, cultured geranium hypocotyls.² It induces defoliation in cotton in greenhouse studies when applied at a concentration of 56 g/ha.³ Thidiazuron also reduces the viability of MDA-MB-231 and MCF-7 breast cancer cell lines in a concentration-dependent manner, as well as increases DNA fragmentation and apoptosis in MDA-MB-231 cells when used at a concentration of 50 µM.⁴ It increases E-cadherin and decreases vimentin levels in, as well as reduces the number of mammospheres formed by, MDA-MB-231 cells when used at a concentration of 50 µM. Formulations containing thidiazuron have been used in the control of plant growth and foliage in agriculture.

WARNING This product is not for human or veterinary use.

1. Thomas, J.C., and Katterman, F.R. Cytokinin activity induced by thidiazuron. Plant Physiol. 81(2), 681-683 (1986).

2. Visser, C., Qureshi, J.A., Gill, R., et al. Morphoregulatory role of thidiazuron: Substitution of auxin and cytokinin requirement for the induction of somatic embryogenesis in geranium hypocotyl cultures. Plant Physiol. 99(4), 1704-1707 (1992).

3. Snipes, C.E., and Wills, G.D. Influence of temperature and adjuvants on thidiazuron activity in cotton leaves. Weed Sci. 42(1), 13-17 (1994).

4. Rajendran, P., Ammar, R.B., Al-Saeedi, F.J., et al. Thidiazuron decreases epithelial-mesenchymal transition activity through the NF-kB and PI3K/AKT signalling pathways in breast cancer. J. Cell. Mol. Med. 24(24), 14525-14538 (2020).