An inhibitor of IKK2
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IKK2 Inhibitor VI

Item No. 17276

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(aminocarbonyl)amino]-5-phenyl-3-thiophenecarboxamide
CAS Number
354811-10-2
Synonyms
  • 5-Phenyl-2-ureidothiophene-3-carboxylic Acid Amide
Molecular Formula
C12H11N3O2S
Formula Weight
261.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 2 mg/ml
λmax
212, 233, 314 nm
SMILES
O=C(N)NC1=C(C(N)=O)C=C(C2=CC=CC=C2)S1
InChi Code
InChI=1S/C12H11N3O2S/c13-10(16)8-6-9(7-4-2-1-3-5-7)18-11(8)15-12(14)17/h1-6H,(H2,13,16)(H3,14,15,17)
InChi Key
PSVUSJKZJQMCSP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $70

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    1 mg

    $123

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    5 mg

    $528

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    Product Description

    IKK2 Inhibitor VI is a potent, cell-permeable, reversible inhibitor of IKK2 (IC50 = 13 nM).1 It is used to evaluate the role of the canonical, IκB-dependent NF-κB signaling pathway in cellular responses.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Baxter, A., Brough, S., Cooper, A., et al. Hit-to-lead studies: The discovery of potent, orally active, thiophenecarboxamide IKK-2 inhibitors. Bioorg. Med. Chem. Lett. 14(11), 2817-2822 (2004).

    2. McNamara, L.A., Ganesh, J.A., and Collins, K.L. Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation. J. Virol. 86(17), 9337-9350 (2012).

    3. Punj, V., Matta, H., and Chaudhary, P.M. A computational profiling of changes in gene expression and transcription factors induced by vFLIP K13 in primary effusion lymphoma. PLoS One 7(5), 1-15 (2012).