A necrosis inhibitor
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Necrox-5 (methanesulfonate)

Item No. 17278

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-7-amine, dimethanesulfonate
CAS Number
1383718-29-3
Synonyms
  • Necrosis Inhibitor 5
  • NecroX-5
Molecular Formula
C25H31N3O3S • 2CH4O3S
Formula Weight
645.8
Purity
≥85%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS(pH 7.2)(1:6): 0.1 mg/mlDMSO: 1 mg/mlEthanol: 0.25 mg/ml
λmax
209, 275, 311 nm
SMILES
O=S(CCN1CC2=CC(NCC3CCOCC3)=C(NC(C4=CC=CC=C4)=C5)C5=C2)(CC1)=O.OS(C)(=O)=O.OS(C)(=O)=O
InChi Code
InChI=1S/C25H31N3O3S.2CH4O3S/c29-32(30)12-8-28(9-13-32)18-20-14-22-16-23(21-4-2-1-3-5-21)27-25(22)24(15-20)26-17-19-6-10-31-11-7-19;2*1-5(2,3)4/h1-5,14-16,19,26-27H,6-13,17-18H2;2*1H3,(H,2,3,4)
InChi Key
ZWWWDIWEZYRVMB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $81

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    1 mg

    $128

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    5 mg

    $395

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    10 mg

    $633

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Necrox-5 is a cell permeable inhibitor of necrosis that also demonstrates strong mitochondrial reactive oxygen species and ONOO- scavenging activity.1 It predominantly localizes in mitochondria, selectively blocking oxidative stress-induced necrotic cell death (0.1 μM necrox-5 inhibits ~50% cell death in H9C2 cells exposed to 400 μM t-BHP).1 This compound has been shown to protect cells from oxidative stress, hypoxia, and cold shock in vitro, as well as carbon tetrachloride-induced liver injury and chronic liver fibrosis in rodent models.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, H.J., Koo, S.Y., Ahn, B.H., et al. NecroX as a novel class of mitochondrial reactive oxygen species and ONOO- scavenger. Arch. Pharm. Res. 33(11), 1813-1823 (2010).