A β3-AR agonist
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Metabolite(s)
36315Mirabegron Impurity 6
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Mirabegron

Item No. 17319

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-N-[4-[2-[[(2R)-2-hydroxy-2-phenylethyl]amino]ethyl]phenyl]-4-thiazoleacetamide
CAS Number
223673-61-8
Synonyms
  • YM-178
Molecular Formula
C21H24N4O2S
Formula Weight
396.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:6): 0.1 mg/mlEthanol: 3 mg/ml
λmax
250 nm
SMILES
O[C@@H](CNCCC1=CC=C(NC(CC2=CSC(N)=N2)=O)C=C1)C3=CC=CC=C3
InChi Code
InChI=1S/C21H24N4O2S/c22-21-25-18(14-28-21)12-20(27)24-17-8-6-15(7-9-17)10-11-23-13-19(26)16-4-2-1-3-5-16/h1-9,14,19,23,26H,10-13H2,(H2,22,25)(H,24,27)/t19-/m0/s1
InChi Key
PBAPPPCECJKMCM-IBGZPJMESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

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    25 mg

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    Product Description

    Mirabegron is an agonist of the β3-adrenergic receptor (β3-AR).1 It induces cAMP accumulation in CHO cells expressing the β3-AR but not the β1- or β2-AR (EC50s = 0.0224, >10, and >10 µM, respectively). Mirabegron reduces contraction induced by carbamoylcholine (Item No. 14486) of isolated rat and human bladder strips (EC50s = 5.1 and 0.78 µM, respectively). It decreases the frequency of isovolumetric rhythmic bladder contractions in anesthetized rats when administered at a dose 3 mg/kg. Formulations containing mirabegron have been used in the treatment of overactive bladder.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takasu, T., Ukai, M., Sato, S., et al. Effect of (R)-2-(2-aminothiazol-4-yl)-4'-{2-[(2-hydroxy-2-phenylethyl)amino]ethyl} acetanilide (YM178), a novel selective β3-adrenoceptor agonist, on bladder function. J. Pharmacol. Exp. Ther. 321(2), 642-647 (2007).