A form of esomeprazole in complex with magnesium
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Esomeprazole Magnesium

Item No. 17326

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(T-4)-bis[6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl-κO]-1H-benzimidazolato-κN3]-magnesium
CAS Number
161973-10-0
Synonyms
  • (–)-Omeprazole Magnesium
  • (S)-Omeprazole Magnesium
Molecular Formula
C34H36MgN6O6S2
Formula Weight
713.1
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/ml
λmax
302 nm
SMILES
CC(C=N1)=C(OC)C(C)=C1CS2=[O][Mg+2]3([N]4=C2[N-]C5=C4C=CC(OC)=C5)[N](C(C=CC(OC)=C6)=C6[N-]7)=C7S(CC8=C(C)C(OC)=C(C)C=N8)=[O]3
InChi Code
InChI=1S/2C17H18N3O3S.Mg/c2*1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h2*5-8H,9H2,1-4H3;/q2*-1;+2
InChi Key
KWORUUGOSLYAGD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $38

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    25 mg

    $74

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    50 mg

    $94

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    Product Description

    Esomeprazole magnesium is a form of the gastric H+/K+-ATPase inhibitor esomeprazole (Item No. 17303) in a 2:1 complex with magnesium.1 It reduces aceclofenac-induced ulcer area and lesion index in the stomach in a rat model of gastric ulcer induced by a non-steroidal anti-inflammatory drug (NSAID) when administered at a dose of 20 mg/kg.2 Formulations containing esomeprazole magnesium have been used as proton pump inhibitors (PPIs) in the treatment of gastroesophageal reflux disease (GERD), H. pylori eradication, and hypersecretory conditions, as well as in the prevention of NSAID-associated gastric ulcers.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Olbe, L., Carlsson, E., and Lindberg, P. A proton-pump inhibitor expedition: The case histories of omeprazole and esomeprazole. Nat. Rev. Drug Discov. 2(2), 132-139 (2003).

    2. Kim, T.H., Thapa, S.K., Lee, D.Y., et al. Pharmacokinetics and anti-gastric ulceration activity of oral administration of aceclofenac and esomeprazole in rats. Pharmaceutics 10(3), 152 (2018).