An H+/K+-ATPase inhibitor
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Esomeprazole (sodium salt)

Item No. 17303

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, sodium salt
CAS Number
161796-78-7
Synonyms
  • (–)-Omeprazole
  • (S)-Omeprazole
Molecular Formula
C17H19N3O3S • Na
Formula Weight
368.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
COC1=CC=C2C(N=C([S@](CC3=C(C)C(OC)=C(C)C=N3)=O)N2)=C1.[Na]
InChi Code
InChI=1S/C17H19N3O3S.Na/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h5-8H,9H2,1-4H3,(H,19,20);/t24-;/m0./s1
InChi Key
HVAJOLFRLWQQQL-JIDHJSLPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

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    Cayman Chemical
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    Product Description

    Esomeprazole is an inhibitor of the gastric H+/K+-ATPase and the (S) enantiomer of omeprazole (Item No. 14880).1 It reversibly inhibits the activity of the H+/K+-ATPase in an enzyme assay. Esomeprazole (30 mg/kg, s.c.) inhibits histamine-induced gastric acid secretion in rats. Formulations containing esomeprazole in complex with magnesium have been used as proton pump inhibitors (PPIs) in the treatment of gastroesophageal reflux disease (GERD), H. pylori eradication, and hypersecretory conditions, as well as in the prevention of non-steroidal anti-inflammatory drug-related gastric ulcer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shin, J.M., and Sachs, G. Restoration of acid secretion following treatment with proton pump inhibitors. Gastroenterology 123(5), 1588-1597 (2002).