A CCR2 chemokine receptor antagonist
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Product Type

Small Molecule Modulators
Receptor Pharmacology
Antagonists

Research Area

RS 504393

Item No. 17330

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-methyl-1'-[2-(5-methyl-2-phenyl-4-oxazolyl)ethyl]-spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-one
CAS Number
300816-15-3
Molecular Formula
C25H27N3O3
Formula Weight
417.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:9): 0.1 mg/mlDMSO: 1 mg/mlEthanol: Slightly soluble
λmax
246, 281 nm
SMILES
CC1=CC=C(NC(OC23CCN(CCC4=C(C)OC(C5=CC=CC=C5)=N4)CC3)=O)C2=C1
InChi Code
InChI=1S/C25H27N3O3/c1-17-8-9-22-20(16-17)25(31-24(29)27-22)11-14-28(15-12-25)13-10-21-18(2)30-23(26-21)19-6-4-3-5-7-19/h3-9,16H,10-15H2,1-2H3,(H,27,29)
InChi Key
ODNICNWASXKNNQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $50

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    5 mg

    $134

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    10 mg

    $218

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    25 mg

    $481

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    Product Description

    RS 504393 is a selective antagonist of the MCP-1 receptor CCR2 (IC50s = 89 nM and >100 μM for CCR2 and CCR1, respectively).1 It has been shown to inhibit MCP-1-stimulated chemotaxis (IC50 = 330 nM) and ischemia-reperfusion injury in kidneys.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mirzadegan, T., Diehl, F., Ebi, B., et al. Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: Binding to a common chemokine receptor motif within the helical bundle. The Journal of Biological Chemisty 275(33), 25562-25571 (2000).

    2. Furuichi, K., Wada, T., Iwata, Y., et al. CCR2 signaling contributes to ischemia-reperfusion injury in kidney. J. Am. Soc. Nephrol. 14(10), 2503-2515 (2003).

    Product Citations

    Ubellacker, J.M., Tasdogan, A., Ramesh, V., et al. Lymph protects metastasizing melanoma cells from ferroptosis. Nature 585(7823), 113-118 (2020).