A GABAB receptor antagonist
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Saclofen

Item No. 17355

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
β-(aminomethyl)-4-chloro-benzeneethanesulfonic acid
CAS Number
125464-42-8
Molecular Formula
C9H12ClNO3S
Formula Weight
249.7
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
0.1 M NaOH: 10 mg/mlDMSO: 0.3 mg/ml
λmax
220 nm
SMILES
ClC1=CC=C(C(CN)CS(O)(=O)=O)C=C1
InChi Code
InChI=1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)
InChi Key
JYLNVJYYQQXNEK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $178

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    50 mg

    $739

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    Product Description

    Saclofen is a sulfonic analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that acts as a competitive antagonist of the GABAB receptor (IC50 = 7.8 µM).1 This compound can be used to determine the functional roles for the GABAB receptor as a mediator of slow inhibitory postsynaptic potentials in the brain.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Drew, C.A., Johnston, G.A.R., Kerr, D.I.B., et al. Inhibition of baclofen binding to rat cerebellar membranes by phaclofen, saclofen, 3-aminopropylphosphonic acid and related GABAB receptor antagonists. Neurosci. Lett. 113(1), 107-110 (1990).