A CXCR2 chemokine receptor antagonist
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Antileukinate

Item No. 17359

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N2-acetyl-L-arginyl-L-arginyl-L-tryptophyl-L-tryptophyl-L-cysteinyl-L-argininamide
CAS Number
138559-60-1
Molecular Formula
C45H66N18O7S
Formula Weight
1003.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
222, 282, 290 nm
SMILES
CC(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=C1C=CC=C2)C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N)=O)=O)CS)=O)=O)=O)=O)CCCNC(N)=N)=O
InChi Code
InChI=1S/C45H66N18O7S/c1-24(64)58-32(14-7-17-54-44(49)50)38(66)60-33(15-8-18-55-45(51)52)39(67)61-34(19-25-21-56-29-11-4-2-9-27(25)29)40(68)62-35(20-26-22-57-30-12-5-3-10-28(26)30)41(69)63-36(23-71)42(70)59-31(37(46)65)13-6-16-53-43(47)48/h2-5,9-12,2
InChi Key
FVRBFNYUBYTVIQ-NGTAMTFRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Cayman Chemical
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    Product Description

    Antileukinate is a synthetic hexapeptide with an acetylated amino terminus and an amidated carboxyl terminus that inhibits the binding of CXC chemokines to the chemokine receptor CXCR2.1,2 It inhibits IL-8 binding to neutrophils (Ki = 2.7-13 µM), prevents neutrophil chemotaxis and β-glucuronidase release, and blocks IL-8-induced skin edema in rabbits.3,4,5 At 53 mg/kg, antileukinate has been shown to protect mice against acute pancreatitis and associated lung injury.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fujisawa, N., Hayashi, S., Kurdowska, A., et al. Inhibition of GROα-induced human endothelial cell proliferation by the α-chemokine inhibitor antileukinate. Cytokine 11(3), 231-238 (1999).

    2. Bhatia, M., and Hegde, A. Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Regul. Pept. 138(1), 40-48 (2007).

    3. Hirayama, S., Shiraishi, T., Shirakusa, T., et al. Prevention of neutrophil migration ameliorates rat lung allograft rejection. Mol. Med. 12(9-10), 208-213 (2006).

    4. Hayashi, S., Kurdowska, A., Cohen, A.B., et al. A synthetic peptide inhibitor for α-chemokines inhibits the growth of melanoma cell lines. J. Clin. Invest. 99(11), 2581-2587 (1997).

    5. Hayashi, S., Kurdowska, A., Miller, E.J., et al. Synthetic hexa- and heptapeptides that inhibit IL-8 from binding to and activating human blood neutrophils. J. Immunol. 154(2), 814-824 (1995).