A multi-kinase inhibitor
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SU 5614

Item No. 17410

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3Z)-5-chloro-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylene]-1,3-dihydro-2H-indol-2-one
CAS Number
1055412-47-9
Molecular Formula
C15H13ClN2O
Formula Weight
272.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mLDMSO: 1 mg/mLEthanol: 0.25 mg/ml
λmax
218, 280, 445 nm
SMILES
ClC1=CC=C2C(/C(C(N2)=O)=C/C3=C(C)C=C(C)N3)=C1
InChi Code
InChI=1S/C15H13ClN2O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,1-2H3,(H,18,19)/b12-7-
InChi Key
XLBQNZICMYZIQT-GHXNOFRVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $128

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    10 mg

    $236

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    25 mg

    $502

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    Product Description

    SU 5614 is a chlorinated derivative of SU 5416 (Item No. 13342) and a multi-kinase inhibitor.1 It inhibits growth and induces apoptosis in Ba/F3 and acute myeloid leukemia (AML) cell lines expressing constitutively active FLT3 (IC50s = 150-650 nM) but not those expressing TEL-ABL, TEL-JAK2, or BCR-ABL (IC50s = >10 μM). SU 5614 also inhibits C-KIT, VEGFR, and PDGFRβ in vitro (IC50s = 0.03, 0.46, and 0.36 μM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Spiekermann, K., Dirschinger, R.J., Schwab, R., et al. The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3. Blood 101(4), 1494-1504 (2003).