A selective adenosine A2B receptor inverse agonist
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MRS1706

Item No. 17417

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-acetylphenyl)-2-[4-(2,3,6,9-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide
CAS Number
264622-53-9
Molecular Formula
C27H29N5O5
Formula Weight
503.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.3 mg/ml
λmax
252, 307 nm
SMILES
CCCN(C(N1CCC)=O)C2=C(NC(C3=CC=C(OCC(NC4=CC=C(C(C)=O)C=C4)=O)C=C3)=N2)C1=O
InChi Code
InChI=1S/C27H29N5O5/c1-4-14-31-25-23(26(35)32(15-5-2)27(31)36)29-24(30-25)19-8-12-21(13-9-19)37-16-22(34)28-20-10-6-18(7-11-20)17(3)33/h6-13H,4-5,14-16H2,1-3H3,(H,28,34)(H,29,30)
InChi Key
ZKUCFFYOQOJLGT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $120

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    10 mg

    $203

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    50 mg

    $835

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    Product Description

    MRS1706 is a selective adenosine A2B receptor inverse agonist with Ki values of 1.39, 157, 112, and 230 nM for human A2B, A1, A2A, and A3 receptors, respectively.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, Y.-C., Ji, X.-d., Melman, N., et al. Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A2B adenosine receptors. J. Med. Chem. 43(6), 1165-1172 (2000).

    2. Li, Q., Ye, K., Blad, C.C., et al. ZM241385, DPCPX, MRS1706 are inverse agonists with different relative intrinsic efficacies on constitutively active mutants of the human adenosine A2B receptor. J. Pharmacol. Exp. Ther. 320(2), 637-645 (2007).