A dopamine D2/D3 receptor antagonist
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Raclopride

Item No. 17422

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2-hydroxy-6-methoxy-benzamide
CAS Number
84225-95-6
Synonyms
  • (S)-(-)-Raclopride
Molecular Formula
C15H20Cl2N2O3
Formula Weight
347.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 15 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 15 mg/mlEthanol: 1 mg/ml
SMILES
OC1=C(Cl)C=C(Cl)C(OC)=C1C(NC[C@@H]2CCCN2CC)=O
InChi Code
InChI=1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1
InChi Key
WAOQONBSWFLFPE-VIFPVBQESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $54

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    10 mg

    $91

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    25 mg

    $185

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    50 mg

    $341

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    Product Description

    Raclopride is a selective dopamine D2/D3 receptor antagonist with Ki values of 1.8, 3.5, 2,400, and 18,000 nM for D2, D3, D4, and D1 receptors, respectively.1 It passes the blood brain barrier and can be used in in vivo binding and autoradiography studies of the dopamine system under normal and pathological conditions such as Huntington’s disease.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seeman, P., and Van Tol, H.H.M. Dopamine receptor pharmacology. Trends Pharmacol. Sci. 15(7), 264-270 (1994).

    2. Lidow, M.S., Goldman-Rakic, P.S., Rakic, P., et al. Dopamine D2 receptors in the cerebral cortex: Distribution and pharmacological characterization with [3H]raclopride. Proc. Natl. Acad. Sci. USA 86(16), 6412-6416 (1989).

    3. Ginovart, N. Imaging the dopamine system with in vivo [11C]raclopride displacement studies: Understanding the true mechanism. Mol. Imaging Biol. 7(1), 45-52 (2005).