An inhibitor of microtubule assembly
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Thiocolchicine

Item No. 17427

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(7S)-5,6,7,9-tetrahydro-1,2,3-trimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-acetamide
CAS Number
2730-71-4
Synonyms
  • NSC 186301
Molecular Formula
C22H25NO5S
Formula Weight
415.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: solubleEthanol: solubleMethanol: soluble
λmax
230, 254, 288, 379 nm
SMILES
O=C1C(SC)=CC=C2C([C@@H](NC(C)=O)CCC3=C2C(OC)=C(OC)C(OC)=C3)=C1
InChi Code
InChI=1S/C22H25NO5S/c1-12(24)23-16-8-6-13-10-18(26-2)21(27-3)22(28-4)20(13)14-7-9-19(29-5)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
InChi Key
CMEGANPVAXDBPL-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $42

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    10 mg

    $79

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    25 mg

    $183

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    100 mg

    $561

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    Cayman Chemical
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    Product Description

    Thiocolchicine is an inhibitor of microtubule assembly (IC50 = 2.5 µM) and a derivative of colchicine (Item No. 9000760).1 It inhibits binding of colchicine to tubulin (Ki = 0.7 µM in a radioligand binding assay). Thiocolchicine inhibits proliferation of MDA-MB-231 and multidrug resistant (MDR) MCF-7 ADRr breast cancer cells (IC50s = 0.6 and 400 nM, respectively) as well MDR CEM-VBL leukemia cells (IC50 = 50 nM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hahn, K.M., Humphreys, W.G., Helms, A.M., et al. Structural requirements for the binding of colchicine analogs to tubulin: The role of the C-10 substituent. Bioor. Med. Chem. Lett. 1(9), 471-476 (1991).

    2. De Vincenzo, R., Scambia, G., Ferlini, C., et al. Antiproliferative activity of colchicine analogues on MDR-positive and MDR-negative human cancer cell lines. Anticancer Drug Des. 12(1), 19-33 (1998).