An inhibitor of microtubule polymerization
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Active Metabolite(s)
352383-demethyl Colchicine
Labeled Version(s)
25280Colchicine-d6
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Colchicine

Item No. 9000760

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-acetamide
CAS Number
64-86-8
Molecular Formula
C22H25NO6
Formula Weight
399.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 25 mg/mlEthanol: 25 mg/ml
λmax
202, 243, 352 nm
SMILES
COC1=C(OC)C=C2C(C(C([C@@H](NC(C)=O)CC2)=C3)=CC=C(OC)C3=O)=C1OC
InChi Code
InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1
InChi Key
IAKHMKGGTNLKSZ-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

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    500 mg

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    Cayman Chemical
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    Product Description

    Colchicine is an inhibitor of microtubule polymerization (IC50 = 3.2 μM) that binds to tubulin, which disrupts spindle formation during mitosis.1 It inhibits growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM.1 Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity when used at a dose of 5 μmol/kg in a mouse model of gout and preventing the deposition of uric acid.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Martino, G.D., Regina, G.L., Coluccia, A., et al. Arylthioindoles, potent inhibitors of tubulin polymerization. J. Med. Chem. 47(25), 6120-6123 (2004).

    2. McCarty, D.J. Urate crystals, inflammation, and colchicine. Arthritis Rheum. 58(2), S20-S24 (2008).

    3. Chia, E.W., Grainger, R., and Harper, J.L. Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: A rationale for use of low-dose colchicine. Br. J. Pharmacol. 153(6), 1288-1295 (2008).