A cell-permeable inhibitor of JMJD2 demethylases
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ML-324

Item No. 17472

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)-benzamide
CAS Number
1222800-79-4
Synonyms
  • CID-44143209
Molecular Formula
C21H23N3O2
Formula Weight
349.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 5 mg/ml
λmax
204, 278 nm
SMILES
CN(C)CCCNC(C1=CC=C(C2=CC(C=CC=N3)=C3C(O)=C2)C=C1)=O
InChi Code
InChI=1S/C21H23N3O2/c1-24(2)12-4-11-23-21(26)16-8-6-15(7-9-16)18-13-17-5-3-10-22-20(17)19(25)14-18/h3,5-10,13-14,25H,4,11-12H2,1-2H3,(H,23,26)
InChi Key
QDBVSOZTVKXUES-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    ML-324 is a cell-permeable inhibitor of JMJD2E (KDM4DL; IC50 = 920 nM) that is inactive against lysine-specific demethylase, LSD1.1,2 It reduces the expression of immediate early genes of Herpes simplex virus (IC50 = ~10 µM) and human cytomegalovirus, blocks viral infection, and suppresses the level of viral reactivation in a ganglia explant model of latently infected mice.1 The effects of ML-324 are reversible, as viral replication resumes after drug withdrawal.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liang, Y., Vogel, J.L., Arbuckle, J.H., et al. Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency. Sci. Transl. Med. 5(167), 1-10 (2013).

    2. Rai, G., Kawamura, A., Tumber, A., et al. Discovery of ML324, a JMJD2 demethylase inhibitor with demonstrated antiviral activity. MH084681, 1-32 (2013).