An inhibitor of activation of Ras
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Ras Inhibitory Peptide

Item No. 17474

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
159088-48-9
Synonyms
  • Sos SH3 Domain Inhibitor​
Molecular Formula
C53H91N19O11
Formula Weight
1170.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: MisciblePBS (pH 7.2): 10 mg/ml
SMILES
[H]N[C@@H](C(C)C)C(N1CCC[C@H]1C(N2CCC[C@H]2C(N3CCC[C@H]3C(N[C@@H](C(C)C)C(N4CCC[C@H]4C(N5CCC[C@H]5C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
InChi Code
InChI=1S/C53H91N19O11/c1-29(2)39(54)48(80)71-27-11-19-37(71)47(79)70-26-10-18-36(70)45(77)69-25-9-17-35(69)44(76)67-40(30(3)4)49(81)72-28-12-20-38(72)46(78)68-24-8-16-34(68)43(75)65-32(14-6-22-62-52(57)58)41(73)64-31(13-5-21-61-51(55)56)42(74)66-33(5
InChi Key
KDEHBKGSNFLJSF-QMAXXTOWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $75

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    1 mg

    $128

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    5 mg

    $553

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    10 mg

    $956

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    Product Description

    Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2.1 It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, N., Batzer, A., Daly, R., et al. Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. Nature 363, 85-88 (1993).