An inhibitor of PKCε translocation
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PKCε Inhibitor Peptide

Item No. 17476

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
182683-50-7
Synonyms
  • Protein Kinase Cɛ Inhibitor Peptide
  • ɛV1-2
Molecular Formula
C37H65N9O13
Formula Weight
844.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/mlPBS (pH 7.2): 5 mg/ml
SMILES
[H]N[C@@H](CCC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N1CCC[C@H]1C(N[C@]([C@@H](C)O)([H])C(O)=O)=O)=O)=O)=O)=O)=O)C)=O
InChi Code
InChI=1S/C37H65N9O13/c1-18(2)16-24(32(53)41-23(10-7-8-14-38)36(57)46-15-9-11-26(46)34(55)45-29(21(6)48)37(58)59)42-33(54)25(17-47)43-35(56)28(19(3)4)44-30(51)20(5)40-31(52)22(39)12-13-27(49)50/h18-26,28-29,47-48H,7-17,38-39H2,1-6H3,(H,40,52)(H,41,53)
InChi Key
KNTBAGOTDJPUJV-XMTFRXHISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $36

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    1 mg

    $55

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    5 mg

    $253

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    10 mg

    $469

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    Product Description

    PKCɛ inhibitor peptide is a synthetic peptide corresponding to an amino acid sequence found in the amino terminal C2 domain of most mammalian forms of PKCɛ.1 It selectively and reversibly inhibits the translocation of PKCɛ to intracellular membranes, blocking activation.1 PKCɛ inhibitor peptide is commonly used in cells to evaluate the role of PKCɛ in various cellular responses.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Johnson, J.A., Gray, M.O., Chen, C.H., et al. A protein kinase C translocation inhibitor as an isozyme-selective antagonist of cardiac function. The Journal of Biological Chemisty 271(40), 24962-24966 (1996).

    2. Schuster, D.J., Kitto, K.F., Overland, A.C., et al. Protein kinase Cε is required for spinal analgesic synergy between delta opioid and alpha-2A adrenergic receptor agonist pairs. J. Neurosci. 33(33), 13538-13546 (2013).

    3. Thomspon, J.W., Dave, K.R., Saul, I., et al. Epsilon PKC increases brain mitochondrial SIRT1 protein levels via heat shock protein 90 following ischemic preconditioning in rats. PLoS One 8(9), 1-12 (2013).

    4. Obis, T., Besalduch, N., Hurtado, E., et al. The novel protein kinase C epsilon isoform at the adult neuromuscular synapse: Location, regulation by synaptic activity-dependent muscle contraction through TrkB signaling and coupling to ACh release. Mol. Brain (2015).