A substrate-competitive inhibitor of PKCζ activity
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PKCζ Pseudosubstrate Inhibitor

Item No. 17482

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-seryl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginylglycyl-L-alanyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-lysyl-L-leucine
CAS Number
799764-07-1
Synonyms
  • Protein Kinase Cζ Pseudosubstrate Inhibitor
Molecular Formula
C76H128N30O16
Formula Weight
1718.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
[H]N[C@@H](CO)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(O)=O)=O)=O)=O)CC1=CNC2=C1C=CC=C2)=O)=O)=O
InChi Code
InChI=1S/C76H128N30O16/c1-6-41(4)59(106-61(111)47(78)39-107)70(120)104-55(35-43-24-26-45(108)27-25-43)68(118)101-52(21-13-31-91-74(83)84)64(114)98-49(19-11-29-89-72(79)80)62(112)95-38-58(109)96-42(5)60(110)97-51(20-12-30-90-73(81)82)63(113)100-54(23-
InChi Key
ISDDDWMHYBTNSA-RRIFIRBXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $106

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    1 mg

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    5 mg

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    Product Description

    PKCζ pseudosubstrate inhibitor is a synthetic peptide that corresponds to a pseudosubstrate domain of this PKC isoform.1 It selectively, reversibly, and substrate-competitively inhibits PKCζ activity and, thus, is used to delineate the signaling functions of PKCζ.2,3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eichholtz, T., de Bont, D.B.A., de Widt, J., et al. A myristoylated pseudosubstrate peptide, a novel protein kinase C inhibitor. The Journal of Biological Chemisty 268(3), 1982-1986 (1993).

    2. Lee, A.W. The role of atypical protein kinase C in CSF-1-dependent Erk activation and proliferation in myeloid progenitors and macrophages. PLoS One 6(10), e25580 (2011).

    3. Dang, P.M.C., Fontayne, A., Hakim, J., et al. Protein kinase C ζ phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst. J. Immunol. 166, 1206-1213 (2001).

    4. Standaert, M.L., Galloway, L., Karnam, P., et al. Protein kinase C-ζ as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. The Journal of Biological Chemisty 272(48), 30075-30082 (1997).