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11076Epigenetics Screening Library (96-Well)
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GSK484 (hydrochloride)

Item No. 17488

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)Epigenetic Chemical Probe Guide (PDF)
Technical Information
CAS Number
1652591-81-5
Formula Weight
510.0
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 25 mg/mlWater: 10 mg/ml
λmax
227, 242, 304 nm
SMILES
O[C@@H]1CCN(C(C2=CC(N=C(C3=CC(C=CC=C4)=C4N3CC5CC5)N6C)=C6C(OC)=C2)=O)C[C@@H]1N.Cl
InChi Code
InChI=1S/C27H31N5O3.ClH/c1-30-25-20(11-18(13-24(25)35-2)27(34)31-10-9-23(33)19(28)15-31)29-26(30)22-12-17-5-3-4-6-21(17)32(22)14-16-7-8-16;/h3-6,11-13,16,19,23,33H,7-10,14-15,28H2,1-2H3;1H/t19-,23+;/m0./s1
InChi Key
MULKOGJHUZTANI-ADMBKAPUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    NET Formation Screening & Analysis Services
    Our experts are here to help.
    • Detection of NET formation ex vivo and screening for modulators using:
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    Product Description

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Citations

    Surolia, R., Li, F.J., Wang, Z., et al. NETosis in the pathogenesis of acute lung injury following cutaneous chemical burns. JCI Insight 6(10), e147564 (2021).

    Li, M., Lin, C., Deng, H., et al. A novel peptidylarginine deiminase 4 (PAD4) inhibitor BMS-P5 blocks formation of neutrophil extracellular traps and delays progression of multiple myeloma. Mol. Cancer Ther. 19(7), 1530-1538 (2020).

    Zhou, Y., An, L.-L., Chaerkady, R., et al. Evidence for a direct link between PAD4-mediated citrullination and the oxidative burst in human neutrophils. Sci. Rep. 8(1), 15228 (2018).