A peptidomimetic of the TNF-α receptor ligand binding site
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TNF-α Antagonist

Item No. 17492

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosyl-L-cysteinyl-L-tryptophyl-L-seryl-L-glutaminyl-L-tyrosyl-L-leucyl-L-cysteinyl-L-tyrosine cyclic (2→8)-disulfide
CAS Number
199999-60-5
Synonyms
  • WP9QY
Molecular Formula
C58H71N11O15S2
Formula Weight
1226.4
Formulation (Request formulation change)
A crystalline solid
Peptide Sequence
YCWSQYLCY
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
[H]N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CO)C(N[C@@H](CCC(N)=O)C(N[C@H](C(N[C@@H](CC(C)C)C1=O)=O)CC2=CC=C(O)C=C2)=O)=O)=O)CC3=CNC4=C3C=CC=C4)=O)CSSC[C@H](N1)C(N[C@H](C(O)=O)CC5=CC=C(O)C=C5)=O)=O)CC6=CC=C(O)C=C6
InChi Code
InChI=1S/C58H71N11O15S2/c1-30(2)21-42-52(77)69-48(57(82)66-45(58(83)84)24-33-11-17-37(73)18-12-33)29-86-85-28-47(68-50(75)39(59)22-31-7-13-35(71)14-8-31)56(81)65-44(25-34-26-61-40-6-4-3-5-38(34)40)54(79)67-46(27-70)55(80)62-41(19-20-49(60)74)51(76)64
InChi Key
OXRZFLLXMORPHO-XCLFSWKQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $134

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    1 mg

    $253

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    5 mg

    $1,058

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    Product Description

    TNF-α antagonist is an exocyclic peptide that mimics the critical TNF-α recognition loop on TNF receptor I complex and, thus, prevents ligand interaction with the receptor.1 By blocking the TNF receptor ligand contact site, this peptide interferes with both activating receptor activator of NF-κB (RANK) and TNF-α’s recruitment and activation of osteoclasts.2 TNF-α antagonist has been used to block bone resorption in the study of systemic bone loss in rheumatoid arthritis and inflammatory bone destruction.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Takasaki, W., Kajino, Y., Kajino, K., et al. Structure-based design and characterization of exocyclic peptidomimetics that inhibit TNFα binding to its receptor. Nat. Biotechnol. 15(12), 1266-1270 (1997).

    2. Aoki, K., Saito, H., Itzstein, C., et al. A TNF receptor loop peptide mimic blocks RANK ligand-induced signaling, bone resorption, and bone loss. J. Clin. Invest. 116(6), 1525-1534 (2006).