A selective β3-adrenoceptor agonist
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CL 316,243 (sodium salt)

Item No. 17499

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(2R)-2-[[(2R)-2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid, disodium salt
CAS Number
138908-40-4
Molecular Formula
C20H18ClNO7 • 2Na
Formula Weight
465.8
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.5 mg/mlPBS (pH 7.2): 3 mg/ml
λmax
285 nm
SMILES
ClC1=CC=CC([C@@H](O)CN[C@H](C)CC2=CC=C(OC(C([O-])=O)(C([O-])=O)O3)C3=C2)=C1.[Na+].[Na+]
InChi Code
InChI=1S/C20H20ClNO7.2Na/c1-11(22-10-15(23)13-3-2-4-14(21)9-13)7-12-5-6-16-17(8-12)29-20(28-16,18(24)25)19(26)27;;/h2-6,8-9,11,15,22-23H,7,10H2,1H3,(H,24,25)(H,26,27);;/q;2*+1/p-2/t11-,15+;;/m1../s1
InChi Key
FUZBPOHHSBDTJQ-CFOQQKEYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    1 mg

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    5 mg

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    10 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    CL 316,243 is a β3-adrenoceptor agonist (EC50 = 3 nM) that is >10,000-fold selective over β1 and β2.1,2 It causes a rapid decrease in blood glucose level in mice and has been used to study the induction of brown adipocytes and to increase thermogenesis in a mouse model of dietary obesity.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bloom, J.D., Dutia, M.D., Johnson, B.D., et al. Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]-amino] propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent β-adrenergic agonist virtually specific for β3 receptors. A promising antidiabetic and antiobesity agent. J. Med. Chem. 35(16), 3081-3084 (1992).

    2. Baker, J.G. The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br. J. Pharmacol. 144(3), 317-322 (2005).

    3. Guerra, C., Koza, R.A., Yamashita, H., et al. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J. Clin. Invest. 102(2), 412-420 (1998).

    4. MacPherson, R.E.K., Castellani, L., Bueadoin, M.S., et al. Evidence for fatty acids mediating CL 316,243-induced reductions in blood glucose in mice. Am. J. Physiol. Endocrinol. Metab. 307(7), E563-E570 (2014).

    Product Citations

    Galmozzi, A., Kok, B.P., Kim, A.S., et al. PGRMC2 is an intracellular haem chaperone critical for adipocyte function. Nature 576 (7785), 138-142 (2019).