A PARP inhibitor and insulin sensitizer
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BGP-15

Item No. 17503

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-hydroxy-3-(1-piperidinyl)propoxy]-3-pyridinecarboximidamide, dihydrochloride
CAS Number
66611-37-8
Molecular Formula
C14H22N4O2 • 2HCl
Formula Weight
351.3
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.25 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
257, 277 nm
SMILES
N=C(NOCC(O)CN1CCCCC1)C2=CC=CN=C2.Cl.Cl
InChi Code
InChI=1S/C14H22N4O2.2ClH/c15-14(12-5-4-6-16-9-12)17-20-11-13(19)10-18-7-2-1-3-8-18;;/h4-6,9,13,19H,1-3,7-8,10-11H2,(H2,15,17);2*1H
InChi Key
ISGGVCWFTPTHIX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $157

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    10 mg

    $274

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    25 mg

    $583

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    BGP-15 is a PARP inhibitor and insulin sensitizer. In perfused heart, it blocks self-ADP-ribosylation of nuclear PARP (Ki = 57 µM) and mono-ADP-ribosylation of GRP78, resulting in decreased levels of reactive oxygen species, lipid peroxidation, and single-strand DNA breaks.1,2 BGP-15 acts as a co-inducer of heat shock protein 72, augmenting expression induced by heat shock factor 1 in adipocytes and skeletal muscles and improving insulin sensitivity.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Halmosi, R., Berente, Z., Osz, E., et al. Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in langendorff heart perfusion system. Mol. Pharmacol. 59(6), 1497-1505 (2001).

    2. Szabados, E., Literati-Nagy, P., Farkas, B., et al. BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase. Biochem. Pharmacol. 59(8), 937-945 (2000).

    3. Chung, J., Nguyen, A.K., Henstridge, D.C., et al. HSP72 protects against obesity-induced insulin resistance. Proc. Natl. Acad. Sci. USA 105(5), 1739-1744 (2008).

    4. Henstridge, D.C., Bruce, C.R., Drew, B.G., et al. Activating HSP72 in rodent skeletal muscle increases mitochondrial number and oxidative capacity and decreases insulin resistance. Diabetes 63, 1881-1894 (2014).