A negative control for SGC707
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XY1

Item No. 17518

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-2-naphthalenyl-N'-[2-oxo-2-(1-pyrrolidinyl)ethyl]-urea
CAS Number
1624117-53-8
Molecular Formula
C17H19N3O2
Formula Weight
297.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
245 nm
SMILES
O=C(NCC(N1CCCC1)=O)NC2=CC3=CC=CC=C3C=C2
InChi Code
InChI=1S/C17H19N3O2/c21-16(20-9-3-4-10-20)12-18-17(22)19-15-8-7-13-5-1-2-6-14(13)11-15/h1-2,5-8,11H,3-4,9-10,12H2,(H2,18,19,22)
InChi Key
GSQHGSRPQHBTTP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $117

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    10 mg

    $218

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    25 mg

    $514

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    50 mg

    $909

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    Product Description

    Protein arginine N-methyltransferase 3 (PRMT3, Item No. 11642) is a predominantly cytoplasmic enzyme that is constitutively expressed.1,2 SGC707 (Item No. 17017) is a potent, selective allosteric inhibitor of PRMT3 (IC50 = 50 nM). It inhibits the methylation of histones in cells with an IC50 value below 1 µM. XY1 is a close analog of SGC707 that is completely inactive against PRMT3 at concentrations as high as 100 µM.3 It is intended to be used as a negative control for SGC707 in studies involving PRMT3 action. See the Structural Genomics Consortium (SGC) website for more information.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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