An L-type calcium channel blocker
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Isomer(s)
41667Darodipine
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Isradipine

Item No. 17536

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3-methyl 5-(1-methylethyl) ester
CAS Number
75695-93-1
Synonyms
  • PN 200-110
Molecular Formula
C19H21N3O5
Formula Weight
371.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/ml
λmax
228, 276, 324 nm
SMILES
CC1=C(C(C(C(OC(C)C)=O)=C(N1)C)C2=CC=CC3=NON=C23)C(OC)=O
InChi Code
InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
InChi Key
HMJIYCCIJYRONP-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    25 mg

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    Product Description

    Isradipine is a selective L-type calcium channel blocker with long-acting antihypertensive activity.1 It demonstrates an EC50 value of 1.4 nM for relaxation of depolarization-induced contractions of rabbit aorta and an EC25 value of 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria.1 By suppressing calcium influx into the cytoplasm and Cav1.2 expression, isradipine has been shown to attenuate β-amyloid oligomer toxicity in an in vitro model of Alzheimer’s disease.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hof, R.P., Scholtysik, G., Loutzenhiser, R., et al. PN 200-110, a new calcium antagonist: Electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta. J. Biomed. Sci. 6(3), 399-406 (1984).

    2. Anekonda, T.S., and Quinn, J.F. Calcium channel blocking as a therapeutic strategy for Alzheimer’s disease: The case for isradipine. Biochim. Biophys. Acta 1812(12), 1584-1590 (2011).