A calcium channel inhibitor
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17536Isradipine
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Darodipine

Item No. 41667

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid, 3,5-diethyl ester
CAS Number
72803-02-2
Synonyms
  • PY 108-068
Molecular Formula
C19H21N3O5
Formula Weight
371.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CC1=C(C(OCC)=O)C(C(C(OCC)=O)=C(N1)C)C2=CC=CC3=NON=C32
InChi Code
InChI=1S/C19H21N3O5/c1-5-25-18(23)14-10(3)20-11(4)15(19(24)26-6-2)16(14)12-8-7-9-13-17(12)22-27-21-13/h7-9,16,20H,5-6H2,1-4H3
InChi Key
QERUYFVNIOLCHV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    Product Description

    Darodipine is a calcium channel inhibitor.1 It selectively inhibits calcium-induced contractions of isolated rabbit aorta (pD2 = 8.8) over norepinephrine-, serotonin-, or angiotensin II-induced contractions at 10 µM. In vivo, continuous infusion of darodipine (2 µg/kg per minute) increases cerebral tissue oxygenation in a cat model of focal ischemia induced by cerebral artery occlusion (CAO).2 Darodipine (5 mg/kg) reduces mean arterial blood pressure and increases arterial luminal area in spontaneously hypertensive rats (SHRs).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hof, R.P., Vuorela, H.J., and Neumann, P. PY 108-068, a new, potent, and selective inhibitor of calcium-induced contraction of rabbit aortic rings. J. Cardiovasc. Pharmacol. 4(3), 344-351 (1982).

    2. Wiernsperger, N., Gygax, P., and Hofmann, A. Calcium antagonist PY 108-068: Demonstration of its efficacy in various types of experimental brain ischemia. Stroke 15(4), 679-685 (1984).

    3. Ferrante, F., Ricci, A., Rossodivita, I., et al. Influence of treatment with the calcium channel blocker darodipine (PY 108-068) on the morphology of pial and coronary arteries in spontaneously hypertensive rats. Clin. Exp. Hypertens. 16(3), 341-357 (1994).