An inhibitor of class III receptor tyrosine kinases
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GTP 14564

Item No. 17543

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-phenyl-1H-benzofuro[3,2-c]pyrazole
CAS Number
34823-86-4
Molecular Formula
C15H10N2O
Formula Weight
234.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.3 mg/mlEthanol: 1 mg/ml
λmax
248, 272, 304 nm
SMILES
C12=CC=CC=C1OC3=C2NN=C3C4=CC=CC=C4
InChi Code
InChI=1S/C15H10N2O/c1-2-6-10(7-3-1)13-15-14(17-16-13)11-8-4-5-9-12(11)18-15/h1-9H,(H,16,17)
InChi Key
DZQLVVLATXPWBK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $36

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    1 mg

    $63

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    5 mg

    $153

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    Product Description

    GTP 14564 is an inhibitor of class III receptor tyrosine kinases (IC50s = 0.3 µM for c-Fms, c-Kit, ITD-FLT3 and 1 µM for PDGFRβ).1 It is without effect against a panel of non-receptor tyrosine and serine/threonine kinases.1 GTP 14564 blocks the proliferation of leukemia cells stimulated with FLT3 ligand by preventing the activation of STAT5.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Murata, K., Kumagai, H., Kawashima, T., et al. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). The Journal of Biological Chemisty 278(35), 32892-32898 (2003).

    2. Yao, Q., Nishiuchi, R., Kitamura, T., et al. Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: The key role of the STAT5 signal transduction pathway. Leukemia 19(9), 1605-1612 (2005).