A selective DNA damage control kinase inhibitor
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Chk2 Inhibitor II

Item No. 17552

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[4-(4-chlorophenoxy)phenyl]-1H-benzimidazole-6-carboxamide
CAS Number
516480-79-8
Synonyms
  • BML-277
  • C 3742
  • Checkpoint Kinase 2 Inhibitor II
Molecular Formula
C20H14ClN3O2
Formula Weight
363.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 10 mg/ml
λmax
282, 256, 314 nm
SMILES
NC(C1=CC=C2C(NC(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3)=N2)=C1)=O
InChi Code
InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
InChi Key
UXGJAOIJSROTTN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $59

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    10 mg

    $106

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    25 mg

    $207

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    50 mg

    $384

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    Product Description

    Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC50 = 15 nM).1 It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC50 = 3-7.6 µM).1 This compound has been used to target the role of Chk2 in cellular signaling in response to DNA damage.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Arienti, K.L., Brunmark, A., Axe, F.U., et al. Checkpoint kinase inhibitors: SAR and radioprotective properties of a series of 2-arylbenzimidazoles. J. Med. Chem. 48(6), 1873-1885 (2005).

    2. Pereg, Y., Lam, S., Teunisse, A., et al. Differential roles of ATM- and Chk2-mediated phosphorylations of Hdmx in response to DNA damage. Mol. Cell. Biol. 26(18), 6819-6831 (2006).