An orally bioavailable HDAC inhibitor
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Resminostat (hydrochloride)

Item No. 17553

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[1-[[4-[(dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-2-propenamide, monohydrochloride
CAS Number
1187075-34-8
Synonyms
  • 4SC-201
  • RAS2410
Molecular Formula
C16H19N3O4S • HCl
Formula Weight
385.9
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.5 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 0.5 mg/ml
λmax
220, 270 nm
SMILES
O=S(N1C=CC(/C=C/C(NO)=O)=C1)(C2=CC=C(CN(C)C)C=C2)=O.Cl
InChi Code
InChI=1S/C16H19N3O4S.ClH/c1-18(2)11-13-3-6-15(7-4-13)24(22,23)19-10-9-14(12-19)5-8-16(20)17-21;/h3-10,12,21H,11H2,1-2H3,(H,17,20);1H/b8-5+;
InChi Key
BVXPKDRKHXARHY-HAAWTFQLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $54

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    5 mg

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    10 mg

    $341

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    50 mg

    $1,042

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    Cayman Chemical
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    Product Description

    Resminostat is an orally bioavailable inhibitor of histone deacetylase 1 (HDAC1), HDAC3, and HDAC6 (IC50s = 43-72 nM), resulting in hyperacetylation of histone H4 in multiple myeloma cells.1 It abrogates cell growth and strongly induces apoptosis in multiple myeloma cells (IC50s = 2.5-3 µM).1 Resminostat displays synergistic effects when combined with melphalan and the proteasome inhibitors bortezomib and S-2209.1 It dose-dependently inhibits HDAC activity in vivo.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mandl-Weber, S., Meinel, F.G., Jankowsky, R., et al. The novel inhibitor of histone deacetylase resminostat (RAS2410) inhibits proliferation and induces apoptosis in multiple myeloma (MM) cells. Br. J. Haematol. 149, 518-528 (2010).

    2. Brunetto, A.T., Ang, J.E., Lal, R., et al. First-in-human, pharmacokinetic and pharmacodynamic phase I study of Resminostat, an oral histone deacetylase inhibitor, in patients with advanced solid tumors. Clin. Cancer Res. 19(19), 5494-5504 (2013).