An isoflavone
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Formononetin

Item No. 17558

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CAS Number
485-72-3
Synonyms
  • Biochanin B
  • NSC 93360
Molecular Formula
C16H12O4
Formula Weight
268.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 25 mg/ml
λmax
249, 301 nm
SMILES
OC1=CC=C(C(C(C2=CC=C(OC)C=C2)=CO3)=O)C3=C1
InChi Code
InChI=1S/C16H12O4/c1-19-12-5-2-10(3-6-12)14-9-20-15-8-11(17)4-7-13(15)16(14)18/h2-9,17H,1H3
InChi Key
HKQYGTCOTHHOMP-UHFFFAOYSA-N
Origin
Plant/Radix Astragali
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 mg

    $36

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    10 mg

    $63

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    25 mg

    $145

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    100 mg

    $469

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    Cayman Chemical
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    Product Description

    Formononetin is an isoflavonoid phytoestrogenic compound found in soy-based foods and is the precursor of daidzein (Item No. 10005166).1 It acts as an agonist of the aryl hydrocarbon receptor with an EC50 value of 0.13 µM.2 Formononetin has been reported to possess antitumor and antiviral activity.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Patisaul, H.B., and Jefferson, W. The pros and cons of phytoestrogens. Front. Neuroendocrinol. 31(4), 400-419 (2010).

    2. Medjakovic, S., and Jungbauer, A. Red clover isoflavones biochanin A and formononetin are potent ligands of the human aryl hydrocarbon receptor. J. Steroid Biochem. Mol. Biol. 108(1-2), 171-177 (2008).

    3. Yang, Y., Zhao, Y., Ai, X., et al. Formononetin suppresses the proliferation of human non-small cell lung cancer through induction of cell cycle arrest and apoptosis. Int. J. Clin. Exp. Pathol. 7(12), 8453-8461 (2014).

    4. Wang, H., Zhang, D., Ge, M., et al. Formononetin inhibits enterovirus 71 replication by regulating COX-2/PGE2 expression. Virol. J. 12, 35 (2015).