4′-Methoxyflavonol

4'-Methoxyflavonol is a synthetic flavonoid.^1,2 It scavenges DPPH (Item No. 14805) radicals in a cell-free assay (IC₅₀ = 25.54 µg/ml).¹ 4'-Methoxyflavonol decreases androgen receptor levels in 22Rv1 prostate cancer cells when used at a concentration of 20 µM and inhibits the proliferation of the same cells (IC₅₀ = 30.5 µM).² In vivo, 4’-methoxyflavonol (10 mg/kg) inhibits acetic acid-induced writhing and decreases immobility time in the forced swim test in mice.¹ It reduces restraint stress-induced increases in adrenal gland weight, blood glucose, triglyceride, and total cholesterol levels, and brain thiobarbituric acid reactive substance (TBARS) levels and increases restraint stress-induced decreases in spleen and brain weight and brain catalase and superoxide dismutase (SOD) levels in mice when administered at a dose of 10 mg/kg.

WARNING This product is not for human or veterinary use.

1. Ghias, M., Shah, S.W.A., Al-Joufi, F.A., et al. In vivo antistress effects of synthetic flavonoids in mice: Behavioral and biochemical approach. Molecules 27(4), 1402 (2022).

2. Britton, R.G., Horner-Glister, E., Pomenya, O.A., et al. Synthesis and biological evaluation of novel flavonols as potential anti-prostate cancer agents. Eur. J. Med. Chem. 54, 952-958 (2012).