A catabolite of threonine and glycine
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Aminoacetone (hydrochloride)

Item No. 17573

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-amino-2-propanone, monohydrochloride
CAS Number
7737-17-9
Synonyms
  • 1-Amino-2-propanone
Molecular Formula
C3H7NO • HCl
Formula Weight
109.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 15 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
CC(CN)=O.Cl
InChi Code
InChI=1S/C3H7NO.ClH/c1-3(5)2-4;/h2,4H2,1H3;1H
InChi Key
RUCLDQBBIJKQHO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $36

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    10 mg

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    50 mg

    $213

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    Cayman Chemical
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    Product Description

    Aminoacetone is a threonine and glycine catabolite that can be converted to methylglyoxal by amine oxidases.1 It has been identified as one of several endogenous sources of methylglyoxal found in the plasma of diabetes patients.2 As a pro-oxidant, 0.10-5 mM aminoacetone can induce cell death in RINm5f pancreatic β-cells.2 Aminoacetone is used as a growth substrate for Pseudomonas.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ray, S., and Ray, M. Formation of methylglyoxal from aminoacetone by amine oxidase from goat plasma. The Journal of Biological Chemisty 258(6), 3461-3462 (1983).

    2. Sartori, A., Garay-Malpartida, H.M., Forni, M.F., et al. Aminoacetone, a putative endogenous source of methylglyoxal, causes oxidative stress and death to insulin-producing RINm5f cells. Chem. Res. Toxicol. 21(9), 1841-1850 (2008).

    3. Higgins, I.J., Pickard, M.A., and Turner, J.M. Aminoacetone formation and utilization by pseudomonads grown on DL-1-aminopropan-2-ol. J. Gen. Microbiol. 54(1), 105-114 (1968).