A CaMKII inhibitor
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Autocamtide-2-related Inhibitory Peptide (trifluoroacetate salt)

Item No. 17590

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-alanyl-L-leucine, 2,2,2-trifluoroacetate
Molecular Formula
C64H116N22O19 • CF3COOH
Formula Weight
1611.8
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCCN)N)=O)CCCCN)=O)C)=O)CC(C)C)=O)CCCNC(N)=N)=O)CCCNC(N)=N)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)C)=O)CC(O)=O)=O)C(C)C)=O)C)=O)CCC(O)=O)=O)CCC(N)=O.
InChi Code
InChI=1S/C64H116N22O19.C2HF3O2/c1-31(2)28-43(83-50(92)34(7)75-54(96)38(17-11-13-25-66)78-53(95)37(67)16-10-12-24-65)60(102)80-40(19-15-27-74-64(71)72)56(98)79-39(18-14-26-73-63(69)70)57(99)81-41(20-22-46(68)87)58(100)82-42(21-23-47(88)89)55(97)76-36(
InChi Key
AQERPQDFAQEHFS-PNTPNKCPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $103

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    5 mg

    $454

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    10 mg

    $753

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    Product Description

    Autocamtide-2-related inhibitory peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase.1,2 It is nonphosphorylatable and selective for CaMKII over PKC, PKA and CaMKIV (IC50s > 10 μM).1,2 This compound is a useful tool for studying the physiological roles of CaMKII.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ishida, A., Kameshita, I., Okuno, S., et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem. Biophys. Res. Commun. 212(3), 806-812 (1995).

    2. Ishida, A., and Fujisawa, H. Stabilization of calmodulin-dependent protein kinase II through autoinhibitory domain. The Journal of Biological Chemisty 270(5), 2163-2170 (1995).

    3. Takasawa, S., Ishida, A., Nata, K., et al. Requirement of calmodulin-dependent protein kinase II in cyclic ADP-ribose-mediated intracellular Ca2+ mobilization. The Journal of Biological Chemisty 270(51), 30257-30259 (1995).