A PPARγ antagonist III
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G3335

Item No. 17593

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tryptophyl-L-glutamic acid
CAS Number
36099-95-3
Molecular Formula
C16H19N3O5
Formula Weight
333.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 5 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
218, 278, 288 nm
SMILES
OC(CC[C@@H](C(O)=O)NC([C@@H](N)CC1=CNC2=C1C=CC=C2)=O)=O
InChi Code
InChI=1S/C16H19N3O5/c17-11(7-9-8-18-12-4-2-1-3-10(9)12)15(22)19-13(16(23)24)5-6-14(20)21/h1-4,8,11,13,18H,5-7,17H2,(H,19,22)(H,20,21)(H,23,24)/t11-,13-/m0/s1
InChi Key
PWIQCLSQVQBOQV-AAEUAGOBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $36

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    25 mg

    $73

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    50 mg

    $107

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    100 mg

    $203

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    Product Description

    G3335 is a cell-permeable dipeptide that potently antagonizes PPARγ (Kd = 8.34 µM).1 It reversibly and competitively blocks activation of PPARγ by rosiglitazone (IC50 = 8-32 µM).1 G3335 is active in vivo, abolishing the protective effects of rosiglitazone in experimental spinal cord injury in rats.2 G3335 has also been used to evaluate the role of PPARγ in neurotoxicity studies.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ye, F., Zhang, Z.S., Luo, H.B., et al. The dipeptide H-Trp-Glu-OH shows highly antagonistic activity against PPARγ: Bioassay with molecular modeling simulation. Chembiochem 7, 74-82 (2006).

    2. Meng, Q.Q., Liang, X.J., Wang, P., et al. Rosiglitazone enhances the proliferation of neural progenitor cells and inhibits inflammation response after spinal cord injury. Neurosci. Lett. 503, 191-195 (2011).

    3. Di Cesare Mannelli, L., Zanardelli, M., Micheli, L., et al. PPAR-γ impairment alters peroxisome functionality in primary astrocyte cell cultures. Biomed Res. Int. 2014, 1-12 (2014).

    4. Zanardelli, M., Micheli, L., Cinci, L., et al. Oxaliplatin neurotoxicity involves peroxisome alterations. PPARγ agonism as preventive pharmacological approach. PLoS One 9(7), 1-15 (2014).