A type 1 angiotensin II receptor agonist
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Angiotensin Fragment 1-7 (acetate)

Item No. 17594

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-L-isoleucine-1-7-angiotensin II
Molecular Formula
C41H62N12O11 • XC2H4O2
Formula Weight
899.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
O=C([C@H](CC1=CNC=N1)NC([C@@]([H])(NC([C@H](CC2=CC=C(C=C2)O)NC([C@@H](NC([C@@H](NC([C@H](CC(O)=O)N)=O)CCCNC(N)=N)=O)C(C)C)=O)=O)[C@H](CC)C)=O)N3CCC[C@H]3C(O)=O.CC(O)=O
InChi Code
InChI=1S/C41H62N12O11.C2H4O2/c1-5-22(4)33(38(61)50-29(17-24-19-45-20-47-24)39(62)53-15-7-9-30(53)40(63)64)52-36(59)28(16-23-10-12-25(54)13-11-23)49-37(60)32(21(2)3)51-35(58)27(8-6-14-46-41(43)44)48-34(57)26(42)18-31(55)56;1-2(3)4/h10-13,19-22,26-30,3
InChi Key
VJHCETPHKAQOHY-LBGFTJIYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $257

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    10 mg

    $481

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Angiotensin fragment 1-7 is an angiotensin metabolite that functions as a type 1 angiotensin II receptor agonist whereupon it can control hydroelectrolyte balance and demonstrates vasodilatory and anti-inflammatory actions in opposition to various adverse effects of angiotensin II (Item No. 17150).1 This peptide can be generated by the action of ACE2, a homolog of ACE, on angiotensin II or by the action of neprilysin on angiotensin I.2 It has been studied in the context of ameliorating the symptoms of metabolic syndrome.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Simoes-e-Silva, A.C., Baracho, N.C.V., Passaglio, K.T., et al. Renal actions of angiotensin-(1-7). Braz. J. Med. Biol. Res. 30(4), 503-513 (1997).

    2. Rice, G.I., Thomas, D.A., Grant, P.J., et al. Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem. J. 383(1), 45-51 (2004).

    3. Purushothaman, K.R., Krishnan, P., Purushothaman, M., et al. Expression of angiotensin-converting enzyme 2 and its end product angiotensin 1-7 is increased in diabetic atheroma: Implications for inflammation and neovascularization. Cardiovasc. Pathol. 22, 42-48 (2013).

    4. Marcus, Y., Shefer, G., Sasson, K., et al. Angiotensin 1-7 as means to prevent the metabolic syndrome: Lessons from the fructose-fed model. Diabetes 62, 1121-1130 (2013).