A methyl donor and cofactor
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Alternative(s)
16376S-(5'-Adenosyl)-L-methionine (tosylate)
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S-(5'-Adenosyl)-L-methionine (sulfate tosylate)

Item No. 17595

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5′-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5′-deoxy-adenosine, monosulfate, 4-methylbenzenesulfonate monosulfate
CAS Number
97540-22-2
Synonyms
  • AdoMet
  • FO 1561
  • SAM
  • SAMe
Molecular Formula
C15H23N6O5S • HSO4 • H2SO4 • C7H8O3S
Formula Weight
766.8
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 10 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
260 nm
SMILES
[H][C@@]1(N2C=NC3=C(N)N=CN=C32)O[C@H](C[S+](C)CC[C@H](N)C(O)=O)[C@@H](O)[C@H]1O.O=S(O)(O)=O.O=S([O-])(O)=O.CC4=CC=C(S(O)(=O)=O)C=C4
InChi Code
InChI=1S/C15H22N6O5S.C7H8O3S.2H2O4S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;1-6-2-4-7(5-3-6)11(8,9)10;2*1-5(2,3)4/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);2-5H,1H3,(H,8,9,10);2*(H2,1,2,3,4)/t7-,8+,10+,11+,14+,27?;;;/m0.../s1
InChi Key
XDCFCHNAIMYBAZ-XQVUROGGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    50 mg

    $54

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    100 mg

    $102

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    250 mg

    $238

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    500 mg

    $315

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    Product Description

    S-(5'-Adenosyl)-L-methionine (SAM) is a methyl donor and cofactor.1 It is involved in several biological processes, including epigenetic regulation, post-translational modification of proteins, and metabolism. Formulations containing SAM have been used as dietary supplements.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Loenen, W.A.M. S-Adenosylmethionine: Jack of all trades and master of everything? Biochem. Soc. Trans. 34(2), 330-333 (2006).

    Product Citations

    Ailabouni, A.S., Vijaywargi, G., Subash, S., et al. Is N1-methylnicotinamide a good organic cation transporter 2 (OCT2) biomarker? Metabolites 15(2), 80 (2025).