AS-1949490

AS-1949490 is a small molecule inhibitor of SHIP2 (IC₅₀s = 0.62 and 0.34 µM for human and mouse, respectively; K_i = 0.44 µM for hSHIP2).¹ It is not as potent an inhibitor of SHIP1, demonstrating inhibitory values 30-fold higher than that of SHIP2, and shows little effect against the phosphatases PTEN, synaptojanin, and myotubularin (IC₅₀s >50 µM).¹ AS-1949490 has been shown to dose-dependently increase insulin-induced phosphorylation of Akt and to activate glucose metabolism.¹ It has also been shown to suppress gluconeogenesis through reduced expression of PEPCK and G6Pase mRNA in normal mice and to decrease plasma glucose in diabetic db/db mice.¹

WARNING This product is not for human or veterinary use.

1. Suwa, A., Yamamoto, T., Sawada, A., et al. Discovery and functional characterization of a novel small molecule inhibitor of the intracellular phosphatase, SHIP2. Br. J. Pharmacol. 158, 879-887 (2009).