A dual PPARα/γ ligand
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LT175

Item No. 17636

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
αS-([1,1'-biphenyl]-4-yloxy)-benzenepropanoic acid
CAS Number
862901-87-9
Molecular Formula
C21H18O3
Formula Weight
318.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 50 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 25 mg/ml
λmax
260 nm
SMILES
O=C(O)[C@H](CC1=CC=CC=C1)OC(C=C2)=CC=C2C3=CC=CC=C3
InChi Code
InChI=1S/C21H18O3/c22-21(23)20(15-16-7-3-1-4-8-16)24-19-13-11-18(12-14-19)17-9-5-2-6-10-17/h1-14,20H,15H2,(H,22,23)/t20-/m0/s1
InChi Key
TZTPJJNNACUQQR-FQEVSTJZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $103

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    10 mg

    $186

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    25 mg

    $420

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Peroxisome proliferator-activated receptors (PPARs) are activated by fatty acids and eicosanoids as well as antidyslipidemic agents. Among the receptor isotypes, PPARα demonstrates a particular role in fatty acid oxidation whereas PPARγ is known to be involved in adipocyte differentiation and lipid storage. LT175 is a dual PPARα/γ ligand that displays partial agonism toward PPARγ (EC50s = 0.22, 0.26, and 0.48 µM for hPPARα, mPPARα, and hPPARγ, respectively).1 It exhibits low adipogenic activity in vitro and improves glucose homeostasis in diet-induced insulin resistant mice.1 LT175 was shown to disrupt the recruitment of coregulators, cyclic-AMP response element-binding protein-binding protein and nuclear corepressor 1, to PPARγ.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gilardi, F., Giudici, M., Mitro, N., et al. LT175 is a novel PPARα/γ ligand with potent insulin-sensitizing effects and reduced adipogenic properties. The Journal of Biological Chemisty 289(10), 6908-6920 (2014).