A potent GPR119 agonist
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APD668

Item No. 17642

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[1-[2-fluoro-4-(methylsulfonyl)phenyl]-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy]-1-piperidinecarboxylic acid, 1-methylethyl ester
CAS Number
832714-46-2
Synonyms
  • JNJ-28630368
Molecular Formula
C21H24FN5O5S
Formula Weight
477.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMF:PBS (pH 7.2) (1:8): 0.1 mg/mlDMSO: 20 mg/ml
λmax
242, 276 nm
SMILES
CC(C)OC(N1CCC(OC2=NC=NC3=C2C=NN3C4=CC=C(S(C)(=O)=O)C=C4F)CC1)=O
InChi Code
InChI=1S/C21H24FN5O5S/c1-13(2)31-21(28)26-8-6-14(7-9-26)32-20-16-11-25-27(19(16)23-12-24-20)18-5-4-15(10-17(18)22)33(3,29)30/h4-5,10-14H,6-9H2,1-3H3
InChi Key
XTRUQJBVQBUKSQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $223

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    10 mg

    $400

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    Cayman Chemical
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    Product Description

    APD668 is a potent agonist of GPR119 (EC50s = 2.7 and 33 nM for human and rat forms, respectively).1 Chronic dosing with APD668 in Zucker diabetic fatty rats over several weeks significantly reduces blood glucose and glycated hemoglobin levels.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Semple, G., Ren, A., Fioravanti, B., et al. Discovery of fused bicyclic agonists of the orphan G-protein coupled receptor GPR119 with in vivo activity in rodent models of glucose control. Bioorg. Med. Chem. Lett. 21(10), 3134-3141 (2011).