A potent, cell-permeable inhibitor of EGFR kinase
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PD 174265

Item No. 17649

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-[(3-bromophenyl)amino]-6-quinazolinyl]-propanamide
CAS Number
216163-53-0
Molecular Formula
C17H15BrN4O
Formula Weight
371.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/ml
λmax
240, 306, 346 nm
SMILES
BrC1=CC(NC2=NC=NC3=C2C=C(NC(CC)=O)C=C3)=CC=C1
InChi Code
InChI=1S/C17H15BrN4O/c1-2-16(23)21-13-6-7-15-14(9-13)17(20-10-19-15)22-12-5-3-4-11(18)8-12/h3-10H,2H2,1H3,(H,21,23)(H,19,20,22)
InChi Key
WUPUZEMRHDROEO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

    $75

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    1 mg

    $134

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    5 mg

    $516

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    Product Description

    PD 174265 is a potent, cell-permeable inhibitor of the tyrosine kinase activity of the epidermal growth factor (EGF) receptor (IC50 = 0.45 nM).1 It is effective in cells, blocking tyrosine phosphorylation induced by either EGF or heregulin (IC50s = 39 and 220 nM, respectively).1 The action of PD 174265 is reversible, which makes it a useful tool for comparative studies with irreversible inhibitors of EGFR kinase activity.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fry, D.W., Bridges, A.J., Denny, W.A., et al. Specific, irreversible inactivation of the epidermal growth factor receptor and erbB2, by a new class of tyrosine kinase inhibitor. Proc. Natl. Acad. Sci. USA 95, 12022-12027 (1998).