An inhibitor of KDR, FLT1, and c-Kit
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VEGFR Tyrosine Kinase Inhibitor II

Item No. 17654

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(4-chlorophenyl)-2-[(4-pyridinylmethyl)amino]-benzamide
CAS Number
269390-69-4
Synonyms
  • Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor II
Molecular Formula
C19H16ClN3O
Formula Weight
337.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 50 mg/mlDMSO: 50 mg/mlDMSO:PBS(pH 7.2) (1:3): 0.25 mg/mlEthanol: 25 mg/ml
λmax
220, 260, 345 nm
SMILES
ClC1=CC=C(NC(C2=CC=CC=C2NCC3=CC=NC=C3)=O)C=C1
InChi Code
InChI=1S/C19H16ClN3O/c20-15-5-7-16(8-6-15)23-19(24)17-3-1-2-4-18(17)22-13-14-9-11-21-12-10-14/h1-12,22H,13H2,(H,23,24)
InChi Key
GGPZCOONYBPZEW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    VEGFR tyrosine kinase inhibitor II is a pyridinyl-anthranilamide compound that inhibits the kinase activities of VEGFR2 (KDR), VEGFR1 (FLT1), and c-Kit (IC50s = 20, 180, and 240 nM, respectively).1 It displays minimal activity against c-Src and EGFR (IC50s = 7 and 7.3 µM, respectively) and is inactive against Cdk1, c-Met, IGF-1R, and PKA (IC50s > 10 µM).1 VEGFR tyrosine kinase inhibitor II has been investigated for its potential to inhibit tumor induced angiogenesis.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Furet, P., Bold, G., Hofmann, F., et al. Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching. Bioorg. Med. Chem. Lett. 13(18), 2967-2971 (2003).