A promoter of β cell proliferation
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Product Categories

Product Type

Biochemicals

Research Area

Endocrinology & Metabolism
Metabolic Diseases
Diabetes

WS6

Item No. 17672

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[[6-[(cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]-benzeneacetamide
CAS Number
1421227-53-3
Molecular Formula
C29H31F3N6O3
Formula Weight
568.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:5): 0.16 mg/mlDMSO: 20 mg/mlEthanol: 20 mg/ml
λmax
244 nm
SMILES
CN1CCN(CC2=CC=C(NC(CC3=CC=C(OC4=CC(NC(C5CC5)=O)=NC=N4)C=C3)=O)C=C2C(F)(F)F)CC1
InChi Code
InChI=1S/C29H31F3N6O3/c1-37-10-12-38(13-11-37)17-21-6-7-22(15-24(21)29(30,31)32)35-26(39)14-19-2-8-23(9-3-19)41-27-16-25(33-18-34-27)36-28(40)20-4-5-20/h2-3,6-9,15-16,18,20H,4-5,10-14,17H2,1H3,(H,35,39)(H,33,34,36,40)
InChi Key
FTODTDQFHDJWIQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    WS6 is a compound that stimulates the proliferation of pancreatic β cells in rodent and human primary islets (ECmax = 200 and 400 nM, respectively, over four days).1,2 It promotes β cell growth in vivo, increasing β cell mass and normalizing blood glucose in the RIP-DTA mouse model of β cell ablation.1 WS6 also stimulates α cell proliferation in human pancreatic islets.3 WS6 appears to act by inhibiting IKKε and blocking the ability of EBP1 to suppress E2F-medtiated transcription.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shen, W., Tremblay, M.S., Deshmukh, V.A., et al. Small-molecule inducer of β cell proliferation identified by highthroughput screening. J. Am. Chem. Soc. 135(5), 1669-1672 (2013).

    2. Corritore, E., Lee, Y.-S., Sokal, E.M., et al. β-cell replacement sources for type 1 diabetes: A focus on pancreatic ductal cells. Ther. Adv. Endocrinol. Metab. 7(4), 182-199 (2014).

    3. Boerner, B.P., George, N.M., Mir, S.U.R., et al. WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability. Endocr. J. 62(4), 379-386 (2015).