A PPARγ agonist
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Darglitazone

Item No. 17681

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[[4-[3-(5-methyl-2-phenyl-4-oxazolyl)-1-oxopropyl]phenyl]methyl]-2,4-thiazolidinedione
CAS Number
141200-24-0
Synonyms
  • CP 86,325
Molecular Formula
C23H20N2O4S
Formula Weight
420.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlEthanol: 5 mg/ml
λmax
202, 253, 279 nm
SMILES
O=C(CCC1=C(C)OC(C2=CC=CC=C2)=N1)C3=CC=C(CC4SC(NC4=O)=O)C=C3
InChi Code
InChI=1S/C23H20N2O4S/c1-14-18(24-22(29-14)17-5-3-2-4-6-17)11-12-19(26)16-9-7-15(8-10-16)13-20-21(27)25-23(28)30-20/h2-10,20H,11-13H2,1H3,(H,25,27,28)
InChi Key
QQKNSPHAFATFNQ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

    $462

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Darglitazone is a TZD that increases the sensitivity of cells to insulin, stimulating insulin-induced PI3K activity at submicromolar concentrations by increasing the expression of the p85 subunit of PI3K.1 It increases insulin effectiveness in obese non-insulin-dependent diabetes mellitus subjects.2 Darglitazone promotes adipocyte differentiation by up-regulating the expression of uncoupling protein-2.3 Through PPARγ, darglitazone restores acute inflammatory responses to cerebral hypoxia-ischemia and reduces infarct size in diabetic ob/ob mice.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

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