An ACC inhibitor
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CP 640,186

Item No. 17691

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[(3R)-1'-(9-anthracenylcarbonyl)[1,4'-bipiperidin]-3-yl]-4-morpholinyl-methanone
CAS Number
591778-68-6
Molecular Formula
C30H35N3O3
Formula Weight
485.6
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
O=C([C@H]1CN(C2CCN(C(C3=C(C=CC=C4)C4=CC5=C3C=CC=C5)=O)CC2)CCC1)N6CCOCC6
InChi Code
InChI=1S/C30H35N3O3/c34-29(32-16-18-36-19-17-32)24-8-5-13-33(21-24)25-11-14-31(15-12-25)30(35)28-26-9-3-1-6-22(26)20-23-7-2-4-10-27(23)28/h1-4,6-7,9-10,20,24-25H,5,8,11-19,21H2/t24-/m1/s1
InChi Key
LDQKDRLEMKIYMC-XMMPIXPASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $167

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    10 mg

    $283

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    25 mg

    $587

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    CP 640,186 is an isozyme-nonselective ACC inhibitor with IC50 values of 53 and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2, respectively.1 It has been shown to lower malonyl-CoA levels and to inhibit hepatic fatty acid and triglyceride synthesis both in vitro and in vivo.1 CP 640,186 can also stimulate muscle fatty acid oxidation (EC50 = 1.3 µM in rat epitrochlearis muscle strips) and lower whole body respiratory quotient in rats (ED50 = ~30 mg/kg).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Harwood, H.J., Jr., Petras, S.F., Shelly, L.D., et al. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. The Journal of Biological Chemisty 278(39), 37099-37111 (2016).

    Product Citations

    Lee, J.Y., Zhu, C., Boldridge, M.A., et al. A multi-functional oral small molecule targeting energy and lipid metabolism to treat obesity and related metabolic disorders. Sci. Adv. 12(34), eaed3119 (2026).