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Tasquinimod

Item No. 17692

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2-dihydro-4-hydroxy-5-methoxy-N,1-dimethyl-2-oxo-N-[4-(trifluoromethyl)phenyl]-3-quinolinecarboxamide
CAS Number
254964-60-8
Synonyms
  • ABR-215050
Molecular Formula
C20H17F3N2O4
Formula Weight
406.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 10 mg/mlEthanol: 2 mg/ml
λmax
232, 303 nm
SMILES
CN(C1=CC=CC(OC)=C1C(O)=C2C(N(C3=CC=C(C(F)(F)F)C=C3)C)=O)C2=O
InChi Code
InChI=1S/C20H17F3N2O4/c1-24(12-9-7-11(8-10-12)20(21,22)23)18(27)16-17(26)15-13(25(2)19(16)28)5-4-6-14(15)29-3/h4-10,26H,1-3H3
InChi Key
ONDYALNGTUAJDX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $392

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    25 mg

    $653

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    Product Description

    Tasquinimod is an orally-active quinoline-3-carboxamide derived from roquinimex, an immunomodulatory quinolone with applications in some cancers and autoimmune diseases.1 Tasquinimod inhibits tumor angiogenesis and supplements radiation or chemotherapy in animal models of prostate cancer.1,2 While its precise mechanism of action remains unclear, tasquinimod has been reported to alter signaling through S100A9, thrombospondin-1, HIF-1α, androgen receptor, VEGF, and HDAC3/4.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Isaacs, J.T. The long and winding road for the development of tasquinimod as an oral second-generation quinoline-3-carboxamide antiangiogenic drug for the treatment of prostate cancer. Expert Opin. Inv. Drugs 19(10), 1235-1243 (2010).

    2. Mehta, A.R., and Armstrong, A.J. Tasquinimod in the treatment of castrate-resistant prostate cancer - current status and future prospects. Ther. Adv. Urol. 8(1), 9-18 (2016).