A selective DYRK1B inhibitor
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AZ191

Item No. 17693

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-methoxy-4-(4-methyl-1-piperazinyl)phenyl]-4-(1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-pyrimidinamine
CAS Number
1594092-37-1
Molecular Formula
C24H27N7O
Formula Weight
429.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 2 mg/mlEthanol: 2 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
λmax
219, 264, 303 nm
SMILES
CN1CCN(C2=CC=C(NC3=NC=CC(C4=CN(C)C5=C4C=CN=C5)=N3)C(OC)=C2)CC1
InChi Code
InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)
InChi Key
ZYVXTMKTGDARKR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $120

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    10 mg

    $219

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    25 mg

    $502

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    Product Description

    AZ191 is a cell-permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50 = 17 nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively.1 This compound has been used as a probe to elucidate the mechanism of DYRK1B regulation of cell cycle progression.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ashford, A.L., Oxley, D., Kettle, J., et al. A novel DYRK1B inhibitor AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr(286), not Thr(288). Biochem. J. 457(1), 43-56 (2014).