A selective Mer kinase inhibitor
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UNC2250

Item No. 17703

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
trans-4-[[2-(butylamino)-5-[5-(4-morpholinylmethyl)-2-pyridinyl]-4-pyrimidinyl]amino]-cyclohexanol
CAS Number
1493694-70-4
Molecular Formula
C24H36N6O2
Formula Weight
440.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
λmax
232, 274, 332 nm
SMILES
CCCCNC1=NC=C(C2=NC=C(CN3CCOCC3)C=C2)C(N[C@@H]4CC[C@@H](O)CC4)=N1
InChi Code
InChI=1S/C24H36N6O2/c1-2-3-10-25-24-27-16-21(23(29-24)28-19-5-7-20(31)8-6-19)22-9-4-18(15-26-22)17-30-11-13-32-14-12-30/h4,9,15-16,19-20,31H,2-3,5-8,10-14,17H2,1H3,(H2,25,27,28,29)/t19-,20-
InChi Key
HSYSSKFCQHXOBP-MXVIHJGJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $36

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    5 mg

    $120

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    10 mg

    $203

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    50 mg

    $667

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    Product Description

    UNC2250 is an inhibitor of Mer kinase activity, blocking the steady-state phosphorylation of endogenous Mer in 697 B-ALL cells with an IC50 value of 9.8 nM.1 It is selective for Mer over a panel of both tyrosine and serine-threonine kinases, including Tyro3 and Axl. UNC2250 also inhibits ligand-dependent phosphorylation of a chimeric EGFR-Mer protein and blocks colony formation in soft agar cultures of BT-12 rhabdoid tumor and Colo699 NSCLC cell lines.1 UNC2250 displays good pharmacokinetic properties in mice following intravenous or oral administration.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, W., Zhang, D., Stashko, M.A., et al. Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. J. Med. Chem. 56(23), 9683-9692 (2013).