A Certified Reference Material
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  • This product is qualified as a Certified Reference Material (CRM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
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XLR11 N-(4-hydroxypentyl) metabolite (CRM)

A 1 mg/ml solution in methanol

Item No. 17727

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[1-(5-fluoro-4-hydroxypentyl)-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)-methanone
CAS Number
1782099-36-8
Molecular Formula
C21H28FNO2
Formula Weight
345.5
Formulation
A 1 mg/ml solution in methanol
SMILES
O=C(C1C(C)(C)C1(C)C)C2=CN(CCCC(O)CF)C3=C2C=CC=C3
InChi Code
InChI=1S/C21H28FNO2/c1-20(2)19(21(20,3)4)18(25)16-13-23(11-7-8-14(24)12-22)17-10-6-5-9-15(16)17/h5-6,9-10,13-14,19,24H,7-8,11-12H2,1-4H3
InChi Key
MDPXVRYUGDTVIS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $129

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    Product Description

    XLR11 (Item No. 11565) is a synthetic cannabinoid (CB) featuring a tetramethylcyclopropyl group, which reportedly confers selectivity for the peripheral CB2 receptor over the central CB1 receptor.1 XLR11 also has an N-(5-fluoropentyl) chain, which increases binding to both CB receptors.2 XLR11 N-(4-hydroxypentyl) metabolite is an expected phase I metabolite of XLR11, based on the known metabolism of similar compounds.3,4 The physiological properties of this compound have not been evaluated. This product is intended for forensic and research applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Frost, J.M., Dart, M.J., Tietje, K.R., et al. Indol-3-ylcycloalkyl ketones: Effects of N1 substituted indole side chain variations on CB2 cannabinoid receptor activity. J. Med. Chem. 53(1), 295-315 (2010).

    2. Makriyannis, A., and Deng, H. Cannabimimetic indole derivatives. US7241799B2, (2001).

    3. Zhang, Q., Ma, P., Cole, R.B., et al. Identification of in vitro metabolites of JWH-015, an aminoalkylindole agonist for the peripheral cannabinoid receptor (CB2) by HPLC-MS/MS. Anal. Bioanal. Chem. 386(5), 1345-1355 (2006).

    4. Wintermeyer, A., Möller, I., Thevis, M., et al. In vitro phase I metabolism of the synthetic cannabimimetic JWH-018. Anal. Bioanal. Chem. 398(5), 2141-2153 (2010).

    Product Citations

    Cho, B., Cho, H.S., Kim, J., et al. Simultaneous determination of synthetic cannabinoids and their metabolites in human hair using LC-MS/MS and application to human hair. Forensic Sci. Int. 306, 110058 (2020).

    Hutter, M., Broecker, S., Kneisel, S., et al. Metabolism of synthetic cannabinoid receptor agonists encountered in clinical casework: Major in vivo phase I metabolites of JWH-007, JWH-019, JWH-203, JWH-307, UR-144, XLR-11, AM-2201, MAM-2201 and AM-694 inhuman urine using LC-MS/MS. Curr. Pharm. Biotechnol. 19(2), 144-162 (2018).