A multi-kinase inhibitor
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AZD 2932

Item No. 17741

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[(6,7-dimethoxy-4-quinazolinyl)oxy]-N-[1-(1-methylethyl)-1H-pyrazol-4-yl]-benzeneacetamide
CAS Number
883986-34-3
Molecular Formula
C24H25N5O4
Formula Weight
447.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 0.25 mg/mlDMSO: 0.25 mg/ml
λmax
239, 320 nm
SMILES
COC1=CC2=C(C(OC3=CC=C(CC(NC4=CN(C(C)C)N=C4)=O)C=C3)=NC=N2)C=C1OC
InChi Code
InChI=1S/C24H25N5O4/c1-15(2)29-13-17(12-27-29)28-23(30)9-16-5-7-18(8-6-16)33-24-19-10-21(31-3)22(32-4)11-20(19)25-14-26-24/h5-8,10-15H,9H2,1-4H3,(H,28,30)
InChi Key
TWYCZJMOEMMCGC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

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    25 mg

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    Product Description

    AZD 2932 is an inhibitor of VEGFR2, PDGFRβ, CSF1R, c-KIT, and FLT3 receptor tyrosine kinases (IC50s = 4, 8, 100, 9, and 7 nM, respectively).1 It also inhibits Pdgfrα phosphorylation (IC50 = 2 nM) in lysates from C6 rat glial tumors grown in athymic mice. AZD 2932 (12.5-50 mg/kg) reduces tumor growth and inhibits Pdgfrβ and Vegfr2 phosphorylation in a 1:1 ratio in a C6 mouse xenograft model. Xenograft models using non-PDGFR expressing tumor cells were insensitive to AZD 2932 treatment.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Plé, P., Jung, F., Ashton, S., et al. Discovery of AZD2932, a new quinazoline ether inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases. Bioorg. Med. Chem. Lett. 22(1), 262-266 (2012).