An atypical neuroleptic
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Perlapine

Item No. 17756

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(4-methyl-1-piperazinyl)-11H-dibenz[b,e]azepine
CAS Number
1977-11-3
Synonyms
  • 6-(4-Methyl-1-piperazinyl)morphanthridine
  • NSC 291840
Molecular Formula
C19H21N3
Formula Weight
291.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 5 mg/ml
λmax
250, 306 nm
SMILES
CN(CC1)CCN1C2=NC(C=CC=C3)=C3CC4=C2C=CC=C4
InChi Code
InChI=1S/C19H21N3/c1-21-10-12-22(13-11-21)19-17-8-4-2-6-15(17)14-16-7-3-5-9-18(16)20-19/h2-9H,10-14H2,1H3
InChi Key
PWRPUAKXMQAFCJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $63

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    5 mg

    $129

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    10 mg

    $190

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    Product Description

    Perlapine is an atypical neuroleptic that blocks dopamine and serotonin (5-HT) receptors (Kis = 60, 30, and 30 nM for D2, D4, and 5-HT2A, respectively).1 Perlapine is also an agonist for hM3Dq, a designer receptor exclusively activated by designer drugs (DREADDs) derived from the human muscarinic acetylcholine M3 receptor that activates neuronal firing.2 Perlapine displays >10,000-fold selectivity for hM3Dq over hM3.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Seeman, P., Corbett, R., and Van Tol, H.H. Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors. Neuropsychopharmacology 16(2), 93-110 (1997).

    2. Chen, X., Choo, H., Huang, X.P., et al. The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. ACS Chem. Neurosci. 6(3), 476-484 (2015).